| Title:
|
„Chladná” moderní elektronová mikroskopie (Czech) |
| Title:
|
“Cold” Electron Microscopy (English) |
| Author:
|
Bednár, Jan |
| Language:
|
Czech |
| Journal:
|
Pokroky matematiky, fyziky a astronomie |
| ISSN:
|
0032-2423 |
| Volume:
|
62 |
| Issue:
|
4 |
| Year:
|
2017 |
| Pages:
|
237-253 |
| Summary lang:
|
Czech |
| . |
| Category:
|
physics |
| . |
| Summary:
|
Mikroskopické techniky v biologii zažívají v posledních letech neobyčejný pokrok a s tím související ocenění. V roce 2008 byla Nobelova cena udělena za objev a práce na zeleném fluorescenčním proteinu, v roce 2014 obdrželi Nobelovu cenu Eric Betzig, Stefan W. Hell a William E. Moerner za práce v oblasti superrezoluční optické mikroskopie. V roce 2017 se k nim připojila elektronová mikroskopie, když se laureáty Nobelovy ceny za chemii stali průkopníci v oblasti elektronové mikroskopie — Jacques Dubochet, Richard Henderson a Joachim Frank. Jejich zásluhou byly položeny zhruba před 35 lety základy moderní elektronové mikroskopie pro použití ve strukturní biologii — takzvané kryoelektronové mikroskopie (kryo-EM), která v současné době zažívá neuvěřitelný rozmach. Zavedení kamer s přímou detekcí elektronů a dalších technologických vylepšení umožňuje pomocí kryo-EM určovat struktury biologických komplexů s rozlišením lepším než 2 Å, tedy na úrovni atomů. Bez průkopnických prací letošních tří laureátů by ovšem nic z toho nebylo možné. (Czech) |
| . |
| Date available:
|
2018-02-07T07:08:21Z |
| Last updated:
|
2019-01-02 |
| Stable URL:
|
http://hdl.handle.net/10338.dmlcz/147066 |
| . |
| Reference:
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