| Title:
|
Regulatory network of drug-induced enzyme production: parameter estimation based on the periodic dosing response measurement (English) |
| Author:
|
Papáček, Štěpán |
| Author:
|
Lynnyk, Volodymyr |
| Author:
|
Rehák, Branislav |
| Language:
|
English |
| Journal:
|
Programs and Algorithms of Numerical Mathematics |
| Volume:
|
Proceedings of Seminar. Hejnice, June 21-26, 2020 |
| Issue:
|
2020 |
| Year:
|
|
| Pages:
|
89-97 |
| . |
| Category:
|
math |
| . |
| Summary:
|
The common goal of systems pharmacology, i.e. systems biology applied to the field of pharmacology, is to rely less on trial and error in designing an input-output systems, e.g. therapeutic schedules. In this paper we present, on the paradigmatic example of a regulatory network of drug-induced enzyme production, the further development of the study published by Duintjer Tebbens \textit{et al}. (2019) in the Applications of Mathematics. Here, the key feature is that the nonlinear model in form of an ODE system is controlled (or periodically forced) by an input signal being a drug intake. Our aim is to test the model features under both periodic and nonrecurring dosing, and eventually to provide an innovative method for a parameter estimation based on the periodic dosing response measurement. (English) |
| Keyword:
|
dynamical system |
| Keyword:
|
regulatory network |
| Keyword:
|
input-output regulation |
| Keyword:
|
parameter estimation |
| Keyword:
|
FFT |
| MSC:
|
34A34 |
| MSC:
|
65F60 |
| MSC:
|
65K10 |
| MSC:
|
92C45 |
| DOI:
|
10.21136/panm.2020.09 |
| . |
| Date available:
|
2021-05-05T13:41:03Z |
| Last updated:
|
2025-06-02 |
| Stable URL:
|
http://hdl.handle.net/10338.dmlcz/703104 |
| . |
