| Title:
|
Fast optical tracking of diffusion in time-dependent environment of brain extracellular space (English) |
| Author:
|
Hrabě, Jan |
| Language:
|
English |
| Journal:
|
Applications of Mathematics 2013 |
| Volume:
|
Proceedings. Prague, May 15-17, 2013 |
| Issue:
|
2013 |
| Year:
|
|
| Pages:
|
117-123 |
| . |
| Category:
|
math |
| . |
| Summary:
|
An improved version of the Integrative Optical Imaging (IOI) method for diffusion measurements in a geometrically complex environment of the brain extracellular space has been developed. We present a theory for this Fast Optical Tracking Of Diffusion (FOTOD) which incorporates a time-dependent effective diffusion coefficient in homogeneous anisotropic media with time-dependent nonspecific linear clearance. FOTOD can be used to measure rapid changes in extracellular diffusion permeability that occur, e.g., during brain insults. The achievable time resolution is approximately one second, a ten fold improvement compared to the traditional IOI method. (English) |
| Keyword:
|
optical tracking of diffusion |
| Keyword:
|
brain extracellular space |
| Keyword:
|
diffusion equation |
| Keyword:
|
Fourier transform |
| Keyword:
|
point spread function |
| MSC:
|
35K15 |
| MSC:
|
35R30 |
| MSC:
|
42B10 |
| MSC:
|
92C55 |
| idZBL:
|
Zbl 1340.92025 |
| idMR:
|
MR3204436 |
| . |
| Date available:
|
2017-02-14T09:16:01Z |
| Last updated:
|
2017-03-20 |
| Stable URL:
|
http://hdl.handle.net/10338.dmlcz/702937 |
| . |
