| Title:
|
Mathematically Modelling The Dissolution Of Solid Dispersions (English) |
| Author:
|
Meere, Martin |
| Author:
|
McGinty, Sean |
| Author:
|
Pontrelli, Giuseppe |
| Language:
|
English |
| Journal:
|
Proceedings of Equadiff 14 |
| Volume:
|
Conference on Differential Equations and Their Applications, Bratislava, July 24-28, 2017 |
| Issue:
|
2017 |
| Year:
|
|
| Pages:
|
341-348 |
| . |
| Category:
|
math |
| . |
| Summary:
|
A solid dispersion is a dosage form in which an active ingredient (a drug) is mixed with at least one inert solid component. The purpose of the inert component is usually to improve the bioavailability of the drug. In particular, the inert component is frequently chosen to improve the dissolution rate of a drug that is poorly soluble in water. The construction of reliable mathematical models that accurately describe the dissolution of solid dispersions would clearly assist with their rational design. However, the development of such models is challenging since a dissolving solid dispersion constitutes a non-ideal mixture, and the selection of appropriate forms for the activity coefficients that describe the interaction between the drug, the inert matrix, and the dissolution medium is delicate. In this paper, we present some preliminary ideas for modelling the dissolution of solid dispersions. (English) |
| Keyword:
|
Solid Dispersion, Mathematical Model, Partial Differential Equations, Activity Coefficients |
| MSC:
|
74N25 |
| MSC:
|
82C70 |
| MSC:
|
82D60 |
| . |
| Date available:
|
2019-09-27T08:20:06Z |
| Last updated:
|
2019-09-27 |
| Stable URL:
|
http://hdl.handle.net/10338.dmlcz/703048 |
| . |
| Reference:
|
[1] Williams, H. D., Trevaskis, N. L., Charman, S. A., Shanker, R. M., N.Charman, W., Pouton, C. W., Porter, C. J. H.: Strategies to address low drug solubility in discovery and development., Pharmacological Reviews, 65 (2013), pp. 315–499. 10.1124/pr.112.005660 |
| Reference:
|
[2] Savjani, K. T., Gajjar, A. K., Savjani, J. K.: Drug solubility: importance andenhancement techniques., ISRN Pharmaceutics, 2012 (2012), pp. 1–10. 10.5402/2012/195727 |
| Reference:
|
[3] Doi, M.: Introduction to polymer physics., Oxford University Press, Oxford, UK, 1996. |
| Reference:
|
[4] Smith, E. B.: Basic chemical thermodynamics., Sixth Ed., Imperial College Press, London, UK, 2014. |
| Reference:
|
[5] Cahn, J. W., Hilliard, J. E.: Free energy of a nonuniform system. I. Interfacial freeenergy., The Journal of Chemical Physics, 28 (1958), pp. 258–267. 10.1063/1.1744102 |
| Reference:
|
[6] Provatas, N., Elder, K.: Phase-field methods in material science and engineering., John Wiley & Sons, 2010. |
| Reference:
|
[7] Huang, Y., Daib, W.: Fundamental aspects of solid dispersion technology for poorly soluble drugs., Acta Pharmaceutica Sinica B, 4(1) (2014), pp. 18–25. 10.1016/j.apsb.2013.11.001 |
| Reference:
|
[8] Brough, C., III, R. O. Williams: Amorphous solid dispersions and nano-crystal technologies for poorly water-soluble drug delivery., International Journal of Pharmaceutics 453 (2013), pp. 157–166. 10.1016/j.ijpharm.2013.05.061 |
| Reference:
|
[9] Craig, D. Q. M.: The mechanisms of drug release from solid dispersions in water-soluble polymers., International Journal of Pharmaceutics, 231 (2002), pp. 131–144. 10.1016/S0378-5173(01)00891-2 |
| Reference:
|
[10] Ahuja, N., Katare, O. P., Singh, B.: Studies on dissolution enhancement and mathematical modeling of drug release of a poorly water-soluble drug using water-soluble carriers., European Journal of Pharmaceutics and Biopharmaceutics, 65 (2007), pp. 26–38. 10.1016/j.ejpb.2006.07.007 |
| Reference:
|
[11] Langham, Z. A., Booth, J., Hughes, L. P., Reynolds, G. K., Wren, S. A. C.: Mechanistic insights into the dissolution of spray-dried amorphous solid dispersions., Journal of Pharmaceutical Sciences, 101(8) (2012), pp. 2798–2810. 10.1002/jps.23192 |
| Reference:
|
[12] Ji, Y., Paus, R., Prudic, A., Lubbert, C., Sadowski, G.: A novel approach for analyzing the dissolution mechanism of solid dispersions., Pharmaceutical Research, 32(2015), pp. 2559–2578. |
| Reference:
|
[13] Kontogeorgis, G. M., Folas, G. K.: Thermodynamic models for industrial applications., First ed., John Wiley & Sons, Chichester, West Sussex, UK, 2010. |
| Reference:
|
[14] Prausnitz, J. M., Lichtenthaler, R. N., Azevedo, E. G. de: Molecular thermodynamics of fluid-phase equilibria., Third ed., Prentice Hall, New Jersey, 1999. |
| Reference:
|
[15] Economou, I. G.: Statistical associating fluid theory: a successful model for the calculation of thermodynamic and phase equilibrium properties of complex fluid mixtures., Industrial & Engineering Chemistry Research, 41 (2002), pp. 953–962. 10.1021/ie0102201 |
| Reference:
|
[16] McCabe, C., Galindo, A.: SAFT associating fluids and fluid mixtures., Applied Thermodynamics of Fluids, Chapter 8, Royal Society of Chemistry, pp. 215–279, 2010. 10.1039/9781849730983-00215 |
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