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Title: Mathematically Modelling The Dissolution Of Solid Dispersions (English)
Author: Meere, Martin
Author: McGinty, Sean
Author: Pontrelli, Giuseppe
Language: English
Journal: Proceedings of Equadiff 14
Volume: Conference on Differential Equations and Their Applications, Bratislava, July 24-28, 2017
Issue: 2017
Pages: 341-348
Category: math
Summary: A solid dispersion is a dosage form in which an active ingredient (a drug) is mixed with at least one inert solid component. The purpose of the inert component is usually to improve the bioavailability of the drug. In particular, the inert component is frequently chosen to improve the dissolution rate of a drug that is poorly soluble in water. The construction of reliable mathematical models that accurately describe the dissolution of solid dispersions would clearly assist with their rational design. However, the development of such models is challenging since a dissolving solid dispersion constitutes a non-ideal mixture, and the selection of appropriate forms for the activity coefficients that describe the interaction between the drug, the inert matrix, and the dissolution medium is delicate. In this paper, we present some preliminary ideas for modelling the dissolution of solid dispersions. (English)
Keyword: Solid Dispersion, Mathematical Model, Partial Differential Equations, Activity Coefficients
MSC: 74N25
MSC: 82C70
MSC: 82D60
Date available: 2019-09-27T08:20:06Z
Last updated: 2019-09-27
Stable URL:
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